Development of Controlled Release Three-layered Diclofenac Tablet

Development of Controlled Release Three-layered Diclofenac Tablet

Автор: Mohammad Arafat,Farhana Sultana and - Manirujjaman

Modified release dosage forms offer definite advantages over conventional release formulation of the same drug.The three-layered matrix system overcomes inherent disadvantages of non-linearity associated with the core, covered by two additional layers, each with different rates of swelling, gelling and erosion, is what accounts for the rate of drug release. When the tablet is first swallowed, the drug concentration is high but the surface area is small. As time goes by and the core swells, the surface area expands to compensate for the decrease in drug concentration. Based on these theoretical considerations the three-layered tablets were designed and Diclofenac Sodium, a weakly acidic drug and widely used NSAID, was taken as the model drug to evaluate the comparative release characteristics from different polymer matrices with different amount with the variation in the outer layers as well as in the core.Then the percent release from different batches of Diclofenac Sodium was plotted…

Impact Of Corporate Governance on Value Creation

Impact Of Corporate Governance on Value Creation

Автор: Farkhanda Abbas

The theme for my thesis on which I have conducted research on, is about the upshots of corporate governance of an organization on the process of creating value while specifically converging on the fashion apparel textile industry of Pakistan. Corporate governance refers to the ways in which a company is controlled by an organizational body by employing ethnicity, laws, norms and policies within the company in order to offer a specific direction and an approach to accomplish the ultimate goal to generate value for the company and the stakeholders. Stakeholders are typically the shareholders, the board of directors, employees, customers, creditors and suppliers of a company and then the community in general. The interactions between the proprietors, executive management, board of directors and other actors direct the effectiveness of the board towards generating value. The decision making culture, headship of the board and customs and norms strategizing reflects the behavior/conduct…

Неотложная алкогольная патология

Неотложная алкогольная патология

Автор: П. П. Огурцов, И. В. Жиров

В книге рассмотрены вопросы диагностики и лечения неотложных состояний и обострений хронических заболеваний, возникновение которых обусловлено систематическим избыточным потреблением алкоголя. Особое внимание уделено выявлению злоупотребляющих алкоголем лиц среди пациентов общемедицинской сети. Для врачей разных специальностей (терапевтов, неврологов, реаниматологов, скорой помощи), а также студентов медицинских учебных заведений.

Коммерческая деятельность в фармацевтике

Коммерческая деятельность в фармацевтике

Автор: Алексей Владимирович Воронов

В работе исследуется российский фармацевтический рынок на современном этапе своего развития. Автором предложена оригинальная классификация розничных фармацевтических предприятий в зависимости от типа, специализации и организационно-правовой формы; разработана методика формирования нового для фармацевтического рынка РФ типа предприятия – аптечной сети, предложен инструментарий организации движения лекарственных препаратов на основе маркетинговых и логистических методов; разработана методика управления запасами групп лекарственных препаратов, характеризующихся сезонными изменениями спроса. Проведенное автором исследование фармацевтического рынка (в том числе прикладные аспекты исследования на примере Приморского края) имеет прикладное значение и его результаты могут быть использованы розничными фармацевтическими предприятиями для определения направлений совершенствования своей деятельности.

Сердечные тропонины в практике врача

Сердечные тропонины в практике врача

Автор: О. В. Крикунова, Р. В. Висков

Монография посвящена актуальным вопросам применения тестов по определению сердечных тропонинов в практике специалистов различного медицинского профиля — как терапевтического, так и хирургического. В книге обсуждаются аспекты диагностической ценности данных тестов при кардиальной и некардиальной патологии, выбора оптимального теста из имеющихся в данный момент на российском рынке, особенности динамики уровней сердечных тропонинов при широком спектре нозологии. Монография рассчитана на читателей, занимающихся проблемой дифференциальной диагностики острого коронарного синдрома, терапевтов, кардиологов, хирургов, неврологов, онкологов, нефрологов, а также студентов медицинских вузов.

Molecular charecterization of poly hydroxy butyrate producing bacteria

Molecular charecterization of poly hydroxy butyrate producing bacteria

Автор: Swati Shalini

Polyhydroxybutyrates are the biopolymers and have a potential to be used as biodegradable plastics to replace synthetic plastics. The present investigation has been undertaken to isolate polyhydroxybutyrate producing bacteria and analyze the diversity among them related with sequence of PHB synthase gene. The soil and water sample for isolation of bacteria were collected from fourteen diverse sources. Out of hundred bacterial isolates forty were found PHB producing after initial fluorescence based screening on Nile blue A containing medium. By trying different combinations of carbon and nitrogen sources 2g glucose as carbon source and 0.65g potassium nitrate was found as most suitable. Six best PHB accumulating strains were selected and characterized for optimization of PHB production media. The selected strains were producing 59-29% PHB of dry weight of cell pellet. Different combinations of Agri-byproducts were tried as carbon source for cost effective PHB production and 3g molasses…

Validation: Essential Requirement in Pharmaceutical Industries

Validation: Essential Requirement in Pharmaceutical Industries

Автор: Rakshit Thumar,Nishendu Nadpara and Umang Hirani

In the pharmaceutical, medical device, food, blood establishments, tissue establishments, and clinical trials industries, validation is the documented act of demonstrating that a procedure, process, and activity will consistently lead to the expected results. It often includes the qualification of systems and equipment. It is a requirement for good manufacturing practices and other regulatory requirements. Since a wide variety of procedures, processes, and activities need to be validated, the field of validation is divided into a number of subsections including the following: Cleaning validation Process validation Analytical method validation Computer system validation this book give the basic idea to the student for under standing to how to validate the process an other cleaning validation

MRI Essentials for the Spine Specialist

MRI Essentials for the Spine Specialist

Автор: A. Jay Khanna

MRI Essentials for the Spine Specialist is a comprehensive textbook that details the complex MRI anatomy of the spine and the spectrum of pathological findings in patients with spinal disorders. Covering basic concepts such as the physics of MRI and normal MRI anatomy of the spine as well as advanced MRI techniques, this book will help clinicians develop a systematic approach to the accurate interpretation of spine MRI studies.Key Features:Region-specific and concept-specific chapters systematically covering what the spine specialist must masterAll chapters written by spine surgeons, interventional pain specialists, and radiologists, specifically for cliniciansMore than 450 MR images and 80 instructive illustrations to help readers visualize and clarify their understanding of the concepts presentedPractical and focused review of how other imaging modalities correlate with and complement MRICommon Clinical Questions with answers and detailed explanations in each chapterThis text will…

Buddhism in Clinical Psychology

Buddhism in Clinical Psychology

Автор: Eman Fallah Psy.D.

Although there have been hundreds of studies on meditation utilizing many different types of manuals, few if any of the protocols rely exclusively on the Buddhist source culture which their mindfulness-based interventions are based on. In reviewing the literature, Dr. Fallah shows how mindfulness investigators fall into one of three research approaches and he makes an argument for how to coherently apply primary source manuals and paradigms as found within other traditions like Buddhism to current social scientific and clinical discourse. Dr. Fallah reviews the role of metacognition in cognitive psychology and provides important points distinguishing metacognitive insight from metacognitive knowledge. Finally, the results of his study in clinically applying the Buddhist text, The Tibetan Book of Living and Dying, is presented.

Role of CCR5?32 Polymorphism in Kashmiri Population

Role of CCR5?32 Polymorphism in Kashmiri Population

Автор: Syed Irtiza Andrabi

Chemokine receptors and their ligands may confer resistance to HIV-1 infection and/or AIDS progression. Our aim was to study our population for the most frequently studied polymorphism CCR5-?32 for evaluating their contribution to a protective genetic background against HIV infection and progression. One hundred and fifty blood samples from normal controls were recruited at random among prospective normal blood donors and forty blood samples of HIV/AIDS patients from Ethnic Kashmiri population were collected from Blood Bank and National AIDS Control Organisation of Sheri Kashmir Institute of Medical Sciences Soura, Kashmir respectively. Genotyping was performed by polymerase chain reaction (PCR) analysis followed by electrophoresis. The CCR5- ?32 genotype frequency among our study group was wt/wt (93.3%), wt/mt (4%) and mt/mt (3%) from control group, revealing CCR5?32 allele frequency of 5%. The frequency of the CCR5- ?32 allele among our study population seems to be remarkably higher…